SKU: 3162844118

Kupfertoxikose (CT) - Labrador Retriever

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Description

Kupfertoxikose (CT) - Labrador RetrieverStoffwechselstrungen des Kupfers sind genetische Strungen des Kupferstoffwechsels in der Leber, die durch Mutationen in zwei Genen verursacht werden, die Kupfertransporter kodieren ATP7A und ATP7B. Der ATP7A Transporter ist entscheidend fr den Kupfertransport von Fibroblasten in die Leber und der ATP7B ist entscheidend fr den Kupferexport aus der Leber. Mutationen im ATP7A fhren zu einem defekten ATP7A Transporter, sodass das Kupfer nicht richtig aus

Stoffwechselstörungen des Kupfers sind genetische Störungen des Kupferstoffwechsels in der Leber, die durch Mutationen in zwei Genen verursacht werden, die Kupfertransporter kodieren – ATP7A und ATP7B. Der ATP7A-Transporter ist entscheidend für den Kupfertransport von Fibroblasten in die Leber und der ATP7B ist entscheidend für den Kupferexport aus der Leber. Mutationen im ATP7A führen zu einem defekten ATP7A-Transporter, sodass das Kupfer nicht richtig aus den Fibroblasten exportiert und in die Leber importiert werden kann, was zu einem Kupfermangel in der Leber führt. Dies führt zu Menkes-Krankheit, einer tödlichen neurodegenerativen Erkrankung, die durch zerebrale und zerebelläre Degeneration, Gedeihstörung, grobes Haar und Bindegewebsanomalien gekennzeichnet ist. Währenddessen führen die Mutationen im ATP7B-Gen zu einem defekten ATP7B-Transporter, sodass das Kupfer nicht richtig aus der Leber exportiert werden kann, was zu einer Kupferansammlung in der Leber und sekundär im Gehirn führt. Dies führt zu Morbus Wilson, was bei mittelalten Hunden zu Zirrhose und neuronaler Degeneration führt. Die Mutation im ATP7A-Gen hat eine X-chromosomale Vererbung und die Mutation im ATP7B-Gen hat eine unvollständig dominante Vererbung. Störungen treten bei Labrador Retrievern und Dobermann Pinschern auf. Bei Dobermann Pinschern werden jedoch Mutationen in beiden Genen gefunden, aber nur die Mutation im ATP7B kann zu einer Störung führen, in diesem Fall Morbus Wilson. Bei Labrador Retrievern können Mutationen nur in einem oder in beiden Genen gleichzeitig vorhanden sein. Mutationen in beiden Genen gleichzeitig können zu einer abnorm hohen Kupferansammlung führen, die zu Kupfertoxikose führt, insbesondere bei Hündinnen.

Vererbung: komplex

Mutation: ATP7A und ATP7B Gen

Gentest: Die Methode, die für den Gentest verwendet wird, ist äußerst genau und ermöglicht eine vollständige Unterscheidung zwischen betroffenen Tieren, Trägern und gesunden Hunden. DNA-Tests können in jedem Alter durchgeführt werden.

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SKU: 3162844118

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4.3 ★★★★★
Based on 22 reviews
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Verified Purchase
Just saying
Phoenix, US
★★★★★ 5
Great product
Color: 2-Speed Rechargeable Set with Charging Base
Great product
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Reviewed in the United States on June 1, 2026
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Verified Purchase
Able
Phoenix, US
★★★★★ 1
Good looker but terrible performance
Color: 2-Speed Rechargeable Set with Charging Base
I purchased the product and the base would not attach from the charging module. This is their big selling point. I requested a replacement and sadly the replacement was of the same batch run as the original soo…. Yeah that base would not detach. There are videos showing how easy it is to detach base from charging module. Not theses units. Circle Joy customer service is an @gmail.com. They said base is not designed to be removed frequently. I reminded them the separation feature is their highlighted feature. I was just looking for a base. Circle Joy said no…. If I do not like either unit just return them to Amazon.???? In the meantime, after maybe a dozen grinds, the original unit quit grinding normally and would barely grind at all. I shook it out and it worked again but doesn’t sound right. Two takeaways: 1) Poor product quality. 2) I am sooo done with trying to work with Amazon on replacement items. Save yourself a tone of aggravation and just return the order and reorder if you dare. Otherwise good looking and heavy feel and works great about 10 times. Too bad so sad. Now I have this huge return hassle with Amazon.
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Reviewed in the United States on February 6, 2026
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Verified Purchase
mohammed shamsuddin
New York, US
★★★★★ 5
Really Effective Utility
Color: Black/Black
I’m extremely impressed with this Electric Salt and Pepper Grinder Set! From the moment I started using it, it made seasoning meals so much easier and more enjoyable. The one-touch operation is incredibly convenient, especially when cooking with both hands occupied. The grinders are powerful, consistent, and produce the perfect grind every time. I also love the adjustable coarseness settings, which let me switch from a fine grind for everyday dishes to a coarser texture for steaks and salads. The build quality feels sturdy and premium, and the modern design looks great on my kitchen counter and dining table. Overall, this grinder set combines style, convenience, and performance perfectly. It’s a fantastic addition to any kitchen and would make a great gift as well. Highly recommended!
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Reviewed in the United States on June 6, 2026
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Verified Purchase
Lauri
Chelsea, US
★★★★★ 5
A Small Luxury That Makes a Big Difference
Color: Black/Black
I absolutely love these salt and pepper grinders. They’re sleek, modern, attractive on the table, and honestly much nicer looking than I expected for the price. They even come with their own little caddy, which keeps everything neat and organized and looks great when guests are over. What I love most is how easy they are to use. You simply press a button and instantly get perfectly ground salt or pepper. No twisting, no awkward grinding with two hands, no effort at all. I especially love this for pepper because I use a lot of it when cooking things like soups, lentils, and large meals. Before, hand grinding would make my arm tired, and sometimes I’d end up with uneven chunks of pepper. With these, the grind is smooth, even, and consistent every time. You just hold the button and move it around — quick, simple, and efficient. They also hold a generous amount of salt and pepper, so you’re not constantly refilling them every few days. Honestly, they make cooking easier, they look beautiful on the table, and they feel much more expensive than they are. Excellent purchase and a fantastic gift idea.
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Reviewed in the United States on May 9, 2026
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Verified Purchase
Priscilla Hunt
Charlottesville, US
★★★★★ 5
Great idea, great product
Color: Black/Black
I’ve been using this electric salt and pepper grinder set for a few weeks now and it’s one of those kitchen upgrades you don’t realize you needed until you have it. the top refill design makes it quick and easy to fill with course salt or peppercorns. It holds a good amount so youre not constantly refilling it I really appreciate that these grinders are rechargeable, and therefore a little more eco friendly. The battery life has been solid so far, and I haven’t had to worry about it dying mid-meal. Using it is super simple, It’s truly one-hand, one-button operation, which makes a big difference when you’re cooking. You can grind seasoning while stirring or holding a pan with your other hand. There’s also an LED light that turns on while grinding, so you can actually see how much seasoning you’re adding—small detail, but surprisingly helpful. There’s a small dial underneath that adjusts the grind size from course to fine. and the salt and pepper come out in a really uniform, consistent grind. Overall, the pros—easy refilling, rechargeable design, adjustable grind size, uniform results, —definitely outweigh the cons. It’s a practical, stylish upgrade that makes everyday cooking feel just a little easier and more polished.
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Reviewed in the United States on April 2, 2026

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