SKU: 65853021844

human bcrp vesicle kit hek293

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Description

human bcrp vesicle kit hek293Das Human BCRP Vesicle Kit enthlt Inside out Membranvesikel aus HEK293 Zellen, die transient das Breast Cancer Resistance Protein (BCRP ABCG2) berexprimieren. Das Kit ermglicht ATP abhngige Substrattransportstudien im High Throughput Format und ist konform mit den FDA (2017) und EMA (2013) Leitlinien zur Charakterisierung von Arzneimittelwechselwirkungen (DDI). Hergestellt von Cell4Pharma. Exklusiv im DACH Raum erhltlich ber SeamlessBio. Transporter

Das Human BCRP Vesicle Kit enthält Inside-out-Membranvesikel aus HEK293-Zellen, die transient das Breast Cancer Resistance Protein (BCRP / ABCG2) überexprimieren. Das Kit ermöglicht ATP abhängige Substrattransportstudien im High-Throughput-Format und ist konform mit den FDA (2017)- und EMA (2013)-Leitlinien zur Charakterisierung von Arzneimittelwechselwirkungen (DDI).
 
Hergestellt von Cell4Pharma. Exklusiv im DACH-Raum erhältlich über SeamlessBio.
 

Transporter-Profil

Name: BCRP, Breast Cancer Resistance Protein, ABCG2, ATP-bindende Kassette Unterfamilie G Mitglied 2
Gen: ABCG2
ATP/AMP-Ratio: >10 (garantiert)
Gewebsexpression: Plazenta, Stammzellen, Prostata, Dünndarm, Gehirn, Dickdarm, Leber, Brustdrüse, Niere
Bekannte Substrate: Estron-3-Sulfat (E1S), Methotrexat, Irinotecan, Pantoprazol, Rosuvastatin, Topotecan, Chlorothiazid, Mitoxantron, SN-38, Glibenclamid
 

Kit-Inhalt (100 Reaktionen)

  • Vesikel-Vial (100 Reaktionen), BCRP-überexprimierende
  • HEK293-abgeleitete Vesikel
  • AMP-ATP-Lösung (100 mM), Cell4Pharma
  • Assay-Puffer, Cell4Pharma

Anwendungen

  • Identifikation von Efflux-Transporter-Substraten
  • Drug-Drug-Interaction-(DDI)-Studien gemäß FDA/EMA-Leitlinien
  • Inhibitionsstudien (IC50-Bestimmung)
  • High-Throughput-Screening (Radiolabel-, Fluoreszenz-, LC-MS-Detektion)

Regulatorische Konformität

Der vesikuläre Transportassay mit BCRP-Vesikeln wird im FDA Drug
Interaction Guidance (2017) und in der EMA-Leitlinie zur Untersuchung von
Arzneimittelinteraktionen (2013) für die Charakterisierung
transporter-vermittelter DDI in der Arzneimittelentwicklung empfohlen.
 

Technische Spezifikationen 

Wirtszelle: HEK293 (humane embryonale Nierenzelle)
Vesikeltyp: Inside-out-Membranvesikel
Format: 100 Reaktionen pro Kit
Detektion: Radiolabel / Fluoreszenz / LC-MS kompatibel
Lagerung: –80 °C
 

Verwandte Produkte

  • Human Control Vesicle Kit (C4PVK009) – empfohlen als Negativkontrolle in BCRP-Transportassays
  • Human Pgp Vesicle Kit (C4PVK010) – für parallele P-gp-Efflux-Messung
  • ciPTEC-OAT1 Assay-Ready Cells – für zellbasierte Nephrotoxizitäts- und Transporterstudien
  • Human Serum AB Male OTC (SeamlessBio) – zur Supplementierung von ciPTEC-Kulturmedien
Alle Produkte auf Anfrage.
Kontakt: [email protected] | Telefon: +49 851 37932226
Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
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  • Delivery to the USA:
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Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
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SKU: 65853021844

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4.4 ★★★★★
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Oscar Z
Boise, US
★★★★★ 4
Mostly great
Size: Daily Essentials Kit
Very good quality cleanser and moisturizer. Those two I would purchase again. Only complaint: Face lotion is light and applies well but has that sunblock scent that lingers.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 19, 2025
S
Verified Purchase
Stephan
Houston, US
★★★★★ 5
Really good product
Size: Daily Essentials Kit
This is a really good product. I usually hate the oiliness of skincare products, but this one is actually pretty light and fresh. My skin feels great after applying it. If you fall asleep without washing your face it does cause you to break out pretty bad though, especially if you shaved that day. As long as you wash it off at night, it's absolutely great.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 21, 2024
L
Verified Purchase
LHR
Port Orchard, US
★★★★★ 3
Sunscreen full of chemicals
Size: Daily Essentials Kit
The cleanser is good. I did not like that the sunscreen has a lot of chemicals in it. They should use titanium oxide instead.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 5, 2026
G
Verified Purchase
Garrett K.
Pawtucket, US
★★★★★ 5
Wife likes it
Size: Daily Essentials Kit
Wife likes the smell. Seems to work good.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 4, 2025
S
Verified Purchase
steve
Draper, US
★★★★★ 1
Incomplete Kit Item Missing
Size: Daily Essentials Kit
Product arrived with contents of the kit outside the original packaging. One item from the kit was missing (eye cream).
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 27, 2025

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