SKU: 45639087282

Zoetis INFORCE 3® Respiratory Vaccine

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Description

Zoetis INFORCE 3® Respiratory VaccineRespiratory disease can challenge young calves and dairy cows immediately before and at calving. INFORCE 3 the market leading cattle respiratory vaccine1, is for the vaccination of healthy cattle, including pregnant cows, to help protect against respiratory disease caused by bovine respiratory syncytial virus (BRSV), infectious bovine rhinotracheitis (IBR) virus and parainfluenza3 (PI3) virus. For dairy herds, INFORCE 3 can be used in calves as young

Respiratory disease can challenge young calves and dairy cows immediately before and at calving. INFORCE 3® the market-leading cattle respiratory vaccine1, is for the vaccination of healthy cattle, including pregnant cows, to help protect against respiratory disease caused by bovine respiratory syncytial virus (BRSV), infectious bovine rhinotracheitis (IBR) virus and parainfluenza3 (PI3) virus. For dairy herds, INFORCE 3 can be used in calves as young as 3 days old, at weaning, before moving to group pens, or with cows and heifers at prefreshening.

Indications
Helps protect against respiratory disease caused by BRSV, IBR and PI3.
Available As

Vials

For use with

Beef

Dairy

How it Works

As an intranasal respiratory vaccine, INFORCE 3® causes a local immune response with viral antibodies produced in the nasal passage where BRSV, IBR and PI3 are most likely to enter the animal’s system.

INFORCE 3® is the first commercially-available intranasal respiratory vaccine to help protect against respiratory disease caused by BRSV, while also protecting against IBR and PI3, to help get cattle off to a healthier, more productive start.

INFORCE 3 has a six-month duration of immunity claim for IBR protection, and a single-nostril administration claim. Additional research also demonstrated no maternal antibody interference for IBR and BRSV.2,3

Safe for all ages, types and classes of cattle

INFORCE 3® is safe for use in all types, ages and classes of cattle. INFORCE 3 was demonstrated safe for use in very young, high-stress calves; weaned and high-stress stocker calves; and pregnant heifers and cows.

The Science Behind Effective Control

  • Intranasal administration works with the animal's immune system for fast, effective response
  • Helps prime the immune system for a memory response to subsequent vaccinations as well as disease challenges
  • Contains proprietary, temperature-sensitive IBR and PI3 strains that replicate most effectively in the upper respiratory tract
  • Stimulates interferon release for protection
  • Helps deliver a healthy start for young dairy calves

Proven Respiratory Disease Protection

  • In two different studies, all calves vaccinated with INFORCE 3 survived severe BRSV challenges in which 100% and 90% of unvaccinated controls either died or had to be humanely euthanized.4,5
  • INFORCE 3 was shown to help prevent respiratory disease caused by IBR and PI3 and reduce level and duration of viral shedding caused by IBR and PI3.6-8
  • A study comparing INFORCE 3 and TSV-2® demonstrated that vaccinating cows and heifers with INFORCE 3  prior to freshening helped support overall positive production:
    • 205 pounds more milk per cow per lactation9
    • Increased income per cow9

Directions

Aseptically rehydrate the freeze-dried vaccine with the sterile diluent provided, mix well and administer 2 mL intranasally using a cannula. Place the 2-mL dose in a single nostril or place 1-mL in each nostril. 

Calves vaccinated before the age of 6 months should be revaccinated after 6 months of age to avoid possible maternal antibody interference with immunization. Annual revaccination with a single dose is recommended. 

For further advice on revaccination frequency, consult your veterinarian.

PRECAUTIONS:

  1. Store at 2°-8°C. Prolonged exposure to higher temperatures and/or direct sunlight may adversely affect potency. Do not freeze.

  2. Use entire contents when first opened.

  3. Sterilized syringes should be used to administer this vaccine. Do not sterilize with chemicals because traces of disinfectant may inactivate the vaccine.

  4. Inactivate unused contents before disposal.

  5. Do not vaccinate within 21 days before slaughter.

  6. Contains gentamicin as preservative.

  7. Fetal health risks associated with the vaccination of pregnant animals with modified live vaccines cannot be unequivocally determined during clinical trials conducted for licensure. Appropriate strategies to address the risks associated with modified live vaccine use in pregnant animals should be discussed with a veterinarian.

  8. As with many vaccines, anaphylaxis may occur after use. Initial antidote of epinephrine is recommended and should be followed with appropriate supportive therapy.

References

  1. Based on number of doses and overall sales of respiratory vaccines. Animalytics Segment Data, Biologicals Therapeutic Category, Ending MAT May 2021.
  2. Mahan SM, Sobecki B, Johnson J, et al. Efficacy of Intranasal Vaccination With a Multivalent Vaccine Containing Temperature-Sensitive Modified-Live Bovine Herpesvirus Type 1 for Protection of Seronegative and Seropositive Calves Against Respiratory Disease. J Am Vet Med Assoc. 2016;248(11):1280-1286.
  3. Ellis JA, Gow SP, Mahan S, Leyh R. Duration of Immunity to Experimental Infection With Bovine Respiratory Syncytial Virus Following Intranasal Vaccination of Young Passively Immune Calves. J Am Vet Med Assoc. 2013;243(11):1602-1608.
  4. Data on file, Study Report No. 3131R-60-08-557, Zoetis Inc.
  5. Data on file, Study Report No. 3131R-60-09-669, Zoetis Inc.
  6. Data on file, Study Report No. 3131R-60-08-548, Zoetis Inc.
  7. Data on file, Study Report No. 3131R-60-09-720, Zoetis Inc.
  8. Data on file, Study Report No. 3131R-60-08-568, Zoetis Inc.
  9. Data on file, Study Report No. 10PETINF01, Zoetis Inc.
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Exchange/Return Notes
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SKU: 45639087282

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Rachel
Omaha, US
★★★★★ 4
Not indestructible, but pretty close!
Size: Yellow, Size: Yellow
I adopted a pit mix a little over a month ago, and so far he's managed to destroy every single toy he's had, including ones meant for aggressive chewers. He's a sucker for a good squeaky toy, and this had good reviews (and was affordable) so I decided to check it out. He's had his corn for a week now, and surprisingly, it's still holding up pretty well - though there are some caveats to that. My boy didn't even want to wait for me to take his corn out of the plastic bag, he too excited to get it. He went to town immediately, to the point where he was sitting in a puddle of his own drool after about an hour. He managed to squeak it (which I couldn't do myself), but still hasn't really gotten the hang of doing so - and the squeaker, when wet, does sound a little... Well, wet. He managed to have bite marks in it within the first six hours. Within a day, there were tiny bits of yellow rubber starting to appear anywhere that he played with this toy. A week later and there are some decent sized chunks missing from the corn - some of which I've had to cut off when they got loose and I worried about him choking on them. He loves his corn cob, and will likely get at least a few more weeks of play out of it before I have to toss it for his safety. I'm unsure of whether the squeaker is still functional, but he seems to love it whether or not it squeaks. Overall, it's not a bad toy for most aggressive chewers, but it will not last forever. The rubber is as heavy as the regular red Kong toys, but it feels slightly softer, which might contribute to his ability to break off little pieces. Make sure you keep an eye on your dog with this toy, or with any other, especially if they are chew goblins. But I'd definitely buy this toy again.
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Reviewed in the United States on October 6, 2024
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Zoltare
Carnegie, US
★★★★★ 5
Solid piece
Size: Yellow
Border Collie loves it. Great for aggressive chewers. Prefers this to the carrot or the pineapple one. Probably better for large dogs than my medium size dog as there is some heft to it.
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Reviewed in the United States on December 25, 2025
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Green earth!
Houston, US
★★★★★ 1
Too soft
Size: Blue
Not good for heavy chewing dogs. Gone in 10 minutes!
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Reviewed in the United States on May 25, 2026
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Corin E.
Bozeman, US
★★★★★ 3
Probably indestructible since your dog won't want to play with it.
Size: Yellow
Boring yellow and rubber chew toy with a weird smell. My dog was not impressed.
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Reviewed in the United States on February 25, 2026
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Jordan Akana
Draper, US
★★★★★ 5
Great chew toy!
Size: Blue
Great chew toy that dogs love! The toy is hard but also soft for comfortable chewing. The plastic is lightweight and does not leave sticky residue. It is super easy to clean so won’t leave the toy smelling like stinky dog!
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Reviewed in the United States on December 27, 2025

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